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	Provedor de dados Nature Precedings (1) Autor Chris J. Armit (1) David J. Harrison (1) Linda Wilson (1) Mark Marsden (1) Rehab J. Al-Jamal (1) Steven D. Shapiro (1) Susan McIntyre (1) Mais... Palavra-chave Pharmacology (1) Tipo do documento Manuscript (1) Ano 2007 (1) País United Kingdom (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Allosteric modulation of beta1 integrin function induces lung repair in animal model of emphysema. Nature Precedings Rehab J. Al-Jamal; Linda Wilson; Chris J. Armit; Susan McIntyre; Mark Marsden; Steven D. Shapiro; David J. Harrison. Emphysema is a progressive lung disease characterised by loss of lung parenchyma with associated functional changes including decreased tissue elastance. Here we report beta1 integrin is a novel target for tissue repair and regeneration in emphysema. We show a single dose of a monoclonal antibody against beta1 integrin induced both functional and structural reversal of elastase-induced lung injury in vivo, and we found that similar matrix remodelling changes occurred in human lung tissue. We also identified a potential mechanism of action as this allosteric modulation of beta1 integrin inhibited elastase-induced caspase activation, F-actin aggregate formation and changes in cellular ATP levels. This was accompanied by maintenance of beta1?integrin levels... Tipo: Manuscript Palavras-chave: Pharmacology. Ano: 2007 URL: http://precedings.nature.com/documents/437/version/1 Registros recuperados: 1 Primeira ... 1 ... Última

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